Here are the main clinical trials of hydroxychloroquine for first responders
NOTE: The clinical term for these studies is PrEP, which stands for Pre-Exposure Prophylaxis. All of the following studies involve PrEP. The studies with the soonest expected date of completion are the Ford Health System (June 30, 2020) and Duke University (July 2020).
Duke University: HERO HCQ Study
Patient-Centered Outcomes Research Institute committing $50 million
double-blind, placebo-controlled, randomized trial with treatment course of 30 days.
15,000 patients at 17 locations in 12 states
Principal investigator: Adrian Hernandez, M.D., cardiologist and executive director of Duke Clinical Research Institute
Estimated primary completion date: July 2020
University of Minnesota with Rising Pharmaceuticals, Inc.
3,500 healthcare workers or household contacts exposed to Covid-19.
Randomized, controlled and quadruple blinded
Principal investigator: Radha Rajasingham, MD
Expected completion date: August 2020.
NYU Langone Health
350 participants, health care workers (HCWs) at high risk of occupational exposure to SARS-CoV-2
Controlled but non-randomized
Principal investigator: Howard Belmont
Expected date of completion: Aug. 1, 2020
Henry Ford Health System, Dearborn Michigan
3,000 participants: healthcare workers (HCW), Nursing Home Workers (NHW), first responders (FR), and Detroit Department of Transportation bus drivers (DDOT) in SE, Michigan
Randomized and triple blinded
Principal investigator: William W. O’Neill
Expected completion date: June 30, 2020.
Oxford University
Randomized, double-blinded, controlled study in healthcare workers throughout Asia, Africa and Europe
Workers in Europe and Africa will receive hydroxychloroquine
Workers in Asia will receive chloroquine
40,000 participants
Expected date of completion: April 2021
Principal contact: William Schilling, MD